派洛宁Y号：92-32-0

派洛宁Y号：92-32-0   
英文名称：Pyronin Y；Pyronin G ；Pyronin J   
其他名称：派洛宁G；焦宁Y；吡罗红Y；吡罗红G；二苯氧杂已胺G    
号：92-32-0    
C17H19ClN2O=302.80    
级别：Ultra Pure Grade   
Em(552nm,50% ethanol)：＞52000   
性状(以下信息仅供参考)：绿色发光结晶。溶于水、醇，溶液为红色，带黄色荧光，不溶于醚。以N,N-二甲基间氨基*为原料制取。熔点：250-260℃   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)用于淋球菌染色(与格兰-巴本汉姆氏染色素合用)    
保存：RT 
派洛宁Y号：92-32-0储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
运输：汽车运输、EMS邮政快递，申通快递等， 款到上海3天内发货；
售后：如您对我们的产品服务及技术指标有特殊要求，请及时通知我方。
存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。
派洛宁Y号：92-32-0主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度Z高，杂质含量Z低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析工作。使用蓝色（深蓝色）标签。
（4）实验试剂（LR：Laboratory reagent），又称四级试剂。
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保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 N-SMase2 (neutral sphingomyelinase 2), also known as NSMASE2 or SMPD3 (sphingomyelin phosphodiesterase 3), is a ubiquitously expressed 655 amino acid member of the magnesium-dependent phosphohydrolase protein family. Localized to the membrane of the Golgi apparatus, N-SMase2 functions to catalyze the hydrolysis of sphingomyelin to form ceramide and phosphocholine—two proteins that mediate cell growth arrest and apoptosis. N-SMase2 is enzymatically activated by unsaturated fatty acids and phosphatidylserine and, through regulation of ceramide synthesis, is involved in growth suppression and postnatal development. Expression of N-SMase2 is upregulated during the G0/G1 phases of the cell cycle and optimal N-SMase2 activity occurs at a slightly basic pH of 7.5. N-SMase2 deficiency is the cause of chondrodysplasia, a genetic disorder characterized by impaired bone growth that leads to short stature, bowlegs and underdeveloped joints.
Function : Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.
Subunit : Belongs to the neutral sphingomyelinase family.
Subcellular Location : Golgi apparatus membrane. Cell membrane. May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue Specificity : Predominantly expressed in brain.
Similarity : Belongs to the neutral sphingomyelinase family.
Database links : UniProtKB/Swiss-Prot: Q9NY59.1
英文名称  Anti-NR2E1/Tailless
中文名称  核受体蛋白NR2E1抗体
派洛宁Y号：92-32-0别    名  hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tll; TLX; XTLL.
浓    度  1mg/1ml
规 格  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit
产品类型  一抗   
研究领域  神经生物学 信号转导 干细胞 表观遗传学 
蛋白分子量  predicted molecular weight: 43kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NR2E1/Tailless
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用   WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.