别名：Conserved nuclear protein NHN1; NHN1; Nuclear protein NHN1; zc3h18; ZCH18_HUMAN; Zinc finger CCCH domain-containing protein 18.
背景介绍：NHN1 is a 953 amino acid nuclear protein that contains one C3H1-type zinc finger and exists as two alternatively spliced isoforms. The gene that encodes NHN1 contains more than 61,500 bases and maps to human chromosome 16q24.2. Encoding over 900 genes and consisting of approximay 90 million base pairs, chromosome 16 makes up nearly 3% of the human genome and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, when mutated, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. Alterations in the CREB gene and NOD2 gene, both of which are located on chromosome 16, results in Rubinstein-Taybi syndrome and Crohn's disease, respectively. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.
核蛋白NHN1抗体，ZC3H18抗体简单介绍：
产品编号：BYK-18459R
英文名称：Anti-NHN1
中文名称：核蛋白NHN1抗体
产品规格：50ul；100ul；200ul；1ml，*
抗体来源 Rabbit or Mouse
克隆类型 Polyclonal or Monoclonal
交叉反应、产品应用 （具体交叉反应与产品应用请或添加客服直接索取）
性 状 Lyophilized or Liquid
浓 度 1mg/ml
核蛋白NHN1抗体，ZC3H18抗体产品信息：
抗原修复（免疫组化石蜡切片）
用于福尔马林固定的石蜡包埋组织芯片需要抗原修复。
福尔马林固定的组织有可能破坏了原来组织的抗原结构，蛋白多肽发生交联，导致部分抗原表位封闭，结合位点减少，所以需要抗原修复，以暴露原来的抗原表位，达到充分显露抗原，以不出现明显脱片现象为佳。
抗原修复的几种常用方法（供参考）
1、 微波炉加热：
在微波炉里加热0.01*缓冲液（pH6.0）至沸腾后将组织芯片放入，断电，间隔5-10分钟，反复1-2次。根据玻片情况可参考采用微波加热“3-5-3法”3分钟温火沸腾后静止5分钟，再温火沸腾3分钟即可。
适用的抗原：来源于人、大鼠、小鼠的组织标本；来源于其他动物种属的组织标本。
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