磷脂酸磷酸酶LPIN3抗体,Anti-Lipin 3抗体 返回列表页

磷脂酸磷酸酶LPIN3抗体,Anti-Lipin 3抗体简单介绍：

产品编号：BYK-18291R

英文名称：Anti-Lipin 3
中文名称：磷脂酸磷酸酶LPIN3抗体

别名：dJ450M14.2; dJ450M14.3; dJ620E11.2; Lipin 3 like; Lipin-3; Lipin-3-like; Lipin3; LIPN3L; LPIN 3; LPIN3; LPIN3_HUMAN; Phosphatidate phosphatase LPIN3; RP4 620E11.3; SMP2.

背景介绍：Humans lipodystrophy is characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. Mice carrying mutations in the fatty liver dystrophy (fld) gene have similar phenotypes. Through positional cloning, the mouse gene responsible for fatty liver dystrophy was isolated and designated Lpin1. The nuclear protein encoded by Lpin1 was named lipin. Lpin1 mRNA was expressed at high levels in adipose tissue and was induced during differentiation of preadipocytes. These results indicated that lipin is required for normal adipose tissue development and provided a candidate gene for human lipodystrophy. Through database searches, mouse and human EST and genomic sequences with similarities to Lpin1 were identified. These included two related mouse genes (Lpin2 and Lpin3) and three human homologs (LPIN1, LPIN2, and LPIN3). Human LPIN1 gene has been mapped to 2p25.; linkages of fat mass and serum leptin levels to this same region have been noted. Human LPIN2 and LPIN3 mapped to chromosomes 18p11 and 20q11-q12, respectively. The mouse genes encoding Lpin1, Lpin2, and Lpin3 mapped to chromosome 12, 17, and 2, respectively.

产品规格：50ul；100ul；200ul；1ml，*

抗体来源 Rabbit or Mouse

克隆类型 Polyclonal or Monoclonal

交叉反应、产品应用 （具体交叉反应与产品应用请或添加客服直接索取）

性    状 Lyophilized or Liquid
浓    度 1mg/ml

磷脂酸磷酸酶LPIN3抗体,Anti-Lipin 3抗体产品信息：

免疫应答

    抗原刺激机体产生相应的抗体，抗体的产生过程即为体液免疫应答过程。

    体液免疫应答的主要*位是淋巴结、脾脏和粘膜下淋巴组织等外周免疫器官，外来抗原进入机体后即被补体致敏或者被DC吞噬，然后随淋巴液进入引流淋巴结。淋巴滤泡中的FDC通过其表面的补体受体捕获被致敏的外来抗原，激活B细胞。位于脾髓质交界区的DC则为T细胞呈递外来抗原肽，启动获得性免疫应答，B细胞在外周成熟、发育过程的zui后阶段是成为专门的合成和分泌抗体分子的浆细胞。浆细胞高尔基体发达、代谢活跃，但没有继续分裂、增殖的能力，也不参与抗原递呈。他们寄居在脾脏或者骨髓中，集中所有的能量生产并分泌抗体分子。抗体分子的重链和轻链在内质网上合成、组装后经高尔基体运输至细胞表面并分泌于胞外。一个浆细胞每秒钟能分泌5000个抗体分子，在外周的浆细胞寿命仅为几天，但是骨髓中的浆细胞寿命可能较长。

免疫应答过程：

1.抗原进入机体；

2.抗原刺激 B淋巴细胞，使之分化增殖成为抗体分泌浆细胞和记忆细胞（初次免疫应答）；

3.抗体主要由浆细胞分泌 ；

4.记忆细胞再次受到特异性抗原刺激后会被激活而成为分泌抗体的浆细胞（再次免疫应答）；

5.记忆B细胞是长命细胞，可以存活数月甚至机体终生

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