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243次膜粘连蛋白11抗体厂价
『别名』56 kDa autoantigen; Annexin A11; Annexin XI; Annexin-11; AnnexinA11; AnnexinXI; ANX 11; ANX A11; ANX11; ANX11_HUMAN; ANXA 11; ANXA11; Autoantigen 56 kD; Calcyclin associated annexin 50; Calcyclin-associated annexin 50; CAP 50; CAP-50; CAP50; OTTHUMP00000059806.
『浓度』1mg/1ml
『规格』0.2ml/200μg
『抗体来源』Rabbit
『克隆类型』polyclonal
『交叉反应』Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep
『产品类型』一抗
『研究领域』细胞生物 信号转导 通道蛋白 细胞粘附分子 细胞膜蛋白
『蛋白分子量』predicted molecular weight: 54kDa
『性状』Lyophilized or Liquid
『免疫原』KLH conjugated synthetic peptide derived from human Annexin A11
『亚型』IgG
『纯化方法』affinity purified by Protein A
『储存液』Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
『产品应用』WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
『保存条件』Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
『产品介绍』The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain, which binds to phospholipids in a Ca2+-dependent manner, and a unique amino terminal region, which may confer binding specificity. The annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. Two forms of Annexin XI, designated A and B, have been identified. Transfection of COS-7 cells with Annexin XI-A, but not Annexin XI-B, causes formation of Annexin XI-associated vesicles.
Function : Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis.
Subunit : Interacts with S100A6 (By similarity). Interacts with PDCD6 in a calcium-dependent manner. Interacts with KIF23 during cytokinesis.
Subcellular Location : Cytoplasm. Melanosome. Nucleus envelope. Nucleus > nucleoplasm. Cytoplasm > cytoskeleton > spindle. Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus (By similarity). Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent.
Similarity : Belongs to the annexin family.
Contains 4 annexin repeats.
Database links : UniProtKB/Swiss-Prot: P50995.1
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