碱性品红号：632-99-5
英文名称：Fuchsin basic；Basic Violet 14；Magenta；Basic magenta；Basic rubin；C.I. 42510
其他名称：碱性复红；品红；盐基品红；碱性紫14；玫苯胺；洋红；深红色；红色苯胺染料；碱性新品红；玫瑰苯胺盐酸盐；(4-(4-氨基苯基)(4-亚氨基环己-2,5-二烯亚基)甲基)-2-甲基本胺盐酸盐；玫瑰色素；4-胺-3-甲苯雙(4-胺苯)甲醇
号：632-99-5
C20H20N3Cl=337.85
级别：IND
干燥失重：≤14.6%
亚硫酸钠试验：合格
灼烧残渣：≤0.2%
性状(以下信息仅供参考)：绿色或黄绿色金属光泽结晶，为品红和副品红(PArArosAnilinE)盐酸盐或乙酸盐的混合物。200℃以上分解。溶于乙醇和戊醇，微溶于水，不溶于乙迷。溶于酒精呈红色；溶于热水呈红紫色，遇浓硫酸呈黄棕色，稀释后几乎无色；水溶液加氢氧化钠液呈带有红色沉淀的几乎无色的液体。Z大吸收波长(乙醇中)543nm(ε93000)。有毒
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)用于配制席夫试剂检测醛类，用于萃取光度法测定某些酸根离子及金属离子。也用于光度法检测溴，亚硝酸盐和二氧化硫。用作极谱分析中的*抑制剂。还用作生化分析的核染料,为Z强的核染料。能使粘朊、弹性组织和嗜品红的颗粒染色。中枢神经的核染色；细菌学中用以鉴别结核杆菌；分析化学中配制席夫试剂检验醛类。用溴酸盐滴定的氧化还原指示剂
保存：RT
碱性品红号：632-99-5储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
运输：汽车运输、EMS邮政快递，申通快递等， 款到上海3天内发货；
售后：如您对我们的产品服务及技术指标有特殊要求，请及时通知我方。
存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。
碱性品红号：632-99-5主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度Z高，杂质含量Z低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析碱性品红号：632-99-5When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Non-T cell activation linker (NTAL), a transmembrane adaptor protein, is also designated membrane-associated adapter molecule, Williams-Beuren syndrome chromosome region 15 protein or LAB (linker of activated B cells). NTAL is present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells, and in monocytes and mast cells, but not in resting T lymphocytes. NTAL becomes rapidly tyrosine-phosphorylated upon cross-linking of the B cell receptor (BCR) or of high-affinity Fc g and Fc e receptors of myeloid cells and then associates with the cytoplasmic signaling molecules. NTAL is highly expressed in spleen, lymph node germinal centers and peripheral blood lymphocytes. Defects in the gene encoding for NTAL may cause the musculo-skeletal and cardio-vascular abnormalities that characterize the rare developmental disorder Williams-Beuren syndrome (WBS).
Function : Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Subunit : When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
Subcellular Location : Cell membrane. Present in lipid rafts.
Tissue Specificity : Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
Post-translational modifications : Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.
May be polyubiquitinated.
DISEASE : Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal
