偶氮膦Ⅲ 号：1914-99-4

偶氮膦Ⅲ 号：1914-99-4  
英文名称：CPA-Ⅲ；Chlorophosphonazo Ⅲ；3,6-Bis[(4-chloro-2-phosphonophenyl)azo]-4,5-dihydroxynaphthalene-2,7-disulphonic acid    
其他名称：偶氮磷Ⅲ；2，7-双(4--2-膦羧苯偶氮)-1，8-二羟基萘-3，6-二磺酸；膦酸偶氮III   
号：1914-99-4    
C22H16Cl2N4O14P2S2?4H2O=801.33   
级别：显色剂   
对稀土金属灵敏度试验：合格   
水溶解试验：合格   
性状(以下信息仅供参考)：紫褐色结晶性粉末。易溶于水，微溶于乙醇和丙同，不溶于乙迷、苯、方。在pH＜3的水溶液中呈玫瑰红色，pH=3的水溶液中呈玫瑰红色略带紫色，pH＞4时转为紫色。在浓硫酸中呈浅绿色。在浓硝酸中分解。在氢氧化钠和碳酸钠溶液中呈浅蓝色。摩尔吸光系数为74，500～75，500，具有比偶氮胂Ⅰ更高的络合性能。   
用途：本品仅供科研，不得用于其它用途。(以下用途仅供参考)分光光度测定铀和钙。可在不同条件下与钙、钡、镁、铜、锌、铅、铁、钴、镍、铍、铝、钇、钍、铈和铵等形成有色络合物   
保存：RT 偶氮膦Ⅲ 号：1914-99-4储存条件：
避光、干燥阴凉处封闭贮存,严禁与有毒、有害物品混放、混运。本品为非危险 产品可按一般化学品运输,轻搬动轻放,防止日晒、雨淋！受热、受潮、受光后易丧失活力,保存期短,因此贮存和运输条件比较苛刻。
运输：汽车运输、EMS邮政快递，申通快递等， 款到上海3天内发货；
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存储：应贮存在干燥清洁避光的环境中，严禁与有毒物质混放，以免污染（保质期为两年）。
偶氮膦Ⅲ 号：1914-99-4主要优级纯、分级纯和化学纯3种：
（1）优级纯（GR：Guaranteed reagent），又称一级品或保证试剂，99.8%，这种试剂纯度Z高，杂质含量Z低，适合于重要精密的分析工作和科学研究工作，使用绿色瓶签。
（2）分析纯（AR），又称二级试剂，纯度很高，99.7%，略次于优级纯，适合于重要分析及一般研究工作，使用红色瓶签。
（3）化学纯（CP），又称三级试剂，≥ 99.5%，纯度与分析纯相差较大，适用于工矿、学校一般分析工作。使用蓝色（深蓝色）标签。
（4）实验试剂（LR：Laboratory reagent），又称四级试剂。
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Subunit : Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50 and MRE11A (By similarity). Interacts with histone H2AFX this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with HJURP, INTS3, KPNA2 and TERF2. Interacts with RBBP8; the interaction links the role of the MRN complex in DNA double-strand break sensing to resection. Interacts with SP100; recruits NBN to PML bodies.
Subcellular Location : Nucleus (By similarity). Nucleus, PML body. Chromosome, omere (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity).
Tissue Specificity : Ubiquitous. Expressed at high levels in testis.
Post-translational modifications : Phosphorylated by ATM in response of ionizing radiation, and such phosphorylation is responsible intra-S phase checkpoint control and omere maintenance.
DISEASE : Nijmegen breakage syndrome (NBS) [MIM:251260]: A disorder characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation, immunodeficiency and predisposition to cancer, particularly to lymphoid malignancies. Note=The disease is caused by mutations affecting the gene represented in this entry.
Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Aplastic anemia (AA) [MIM:609135]: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Note=Defects in NBN might play a role in the pathogenesis of childhood acute lymphoblastic leukemia (ALL).
偶氮膦Ⅲ 号：1914-99-4Similarity : Contains 1 BRCT domain.
Contains 1 FHA domain.
Database links : UniProtKB/Swiss-Prot: O60934.1
英文名称  Anti-NRIP
中文名称  雄激素受体复合物相关蛋白/核受体相互作用蛋白抗体
别    名  Androgen receptor complex associated protein; ARCAP; IQ motif and WD repeats 1; IQWD1v MSTP055; Nuclear receptor interaction protein; RP4 745I14.1; DCAF6_HUMAN.
浓    度  1mg/1ml
规 格  0.2ml/200μg
抗体来源  Rabbit 
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit
产品类型  一抗   
研究领域  肿瘤 心血管 染色质和核信号 信号转导 
蛋白分子量  predicted molecular weight: 96kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human NRIP
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user. 
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.