公司提供的甲基-β-D-葡糖苷号：709-50-2*，货源充足。严格的生产质量控制体系，包括：优级纯，分析纯，化学纯，试剂级，基准试剂，实验纯，教学试剂，高纯试剂，色谱纯，光谱纯，电子纯。各种包装规格，并可提供包装定制，咨询订购。
甲基-β-D-葡糖苷号：709-50-2
英文名称：Methyl β-D-glucopyranoside；Methyl β-D-glucoside
其他名称：甲基-β-D-吡喃葡萄糖苷；甲基-β-D-葡糖甙
号：709-50-2
C7H14O6=194.18
级别：BR
含量：≥98%(GC)
熔点：109～112℃
比旋光度：-31～-35o(C=5，H2O)
性状(以下信息仅供参考)：白色粉末，溶于水：100mg/ml
用途：本品仅供科研，不得用于其它用途
保存：RT 客户根据甲基-β-D-葡糖苷号：709-50-2性质、化学式、分子式、结构式、比重、密度、号、沸点、熔点、水溶性、MSDS、用途、作用、规格包装、性状、注意事项、英文名、别称、纯度、级别等情况，本产品化学性质稳定，运输条件不苛刻，一般储存在阴凉，干燥，通风良好的地方，远离不相容的物质。保持容器密闭。
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性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SLC12A6/KCC3
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
Function : K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The SLC12A6 protein is activated by cell swelling induced by hypotonic conditions. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy (ACCPN). ACCPN is characterised by severe progressive sensorimotor neuropathy, mental retardation, dysmorphic features, and partial or complete agenesis of the corpus callosum. The SLC12Ag gene is a candidate gene for schizophrenia and has also been associated with bipolar disease.
Subunit : Homomultimer and heteromultimer with other K-Cl cotransporters
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
Post-translational modifications : N-glycosylated.
DISEASE : Defects in SLC12A6 are a cause of agenesis of the corpus callosum with peripheral neuropathy (ACCPN) [MIM:218000]. ACCPN is characterized by severe progressive sensorimotor neuropathy, mental retardation, dysmorphic features and complete or partial agenesis of the corpus callosum.
Similarity : Belongs to the SLC12A transporter family.
Database links : UniProtKB/Swiss-Prot: Q9UHW9.2
英文名称 Anti-SLC25A12/ARALAR
中文名称 钙结合线粒体载体蛋白抗体
别 名 AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse
产品类型 一抗
研究领域 肿瘤 细胞生物 神经生物学 信号转导 细胞类型标志物 新陈代谢
蛋白分子量 predicted molecular weight: 75kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.
Function : Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle.
Subcellular Location : Mitochondrion inner membrane.
Tissue Specificity : High levels in heart and skeletal muscle, low in brain and very low in kidney.
DISEASE : Defects in SLC25A12 are the cause of aspartate-glutamate carrier 1 deficiency (AGC1D) [MIM:612949]; also called global cerebral hypomyelination. This syndrome consists of a child severe psychomotor retardation, hypotonia and hypomyelination of the central nervous system.
Similarity : Belongs to the mitochondrial carrier family.
Contains 4 EF-hand domains.
Contains 3 Solcar repeats.
Database links : UniProtKB/Swiss-Prot: O75746.2
英文名称 Anti-SLC5A3/SMIT
中文名称 钠离子肌醇转运蛋白抗体
